中文名 | Stilbamidine |
英文名 | Stilbamidine |
别名 | 司替巴脒 化合物 T13905 |
英文别名 | Ba 2652 Stilbamidin STILBAMIDINE stilbamidine Stilbamidine 4,4'-Stilbenedicarboxamidine 2-(2-phenylethenyl)benzenecarboximidamide Benzenecarboximidamide, 4,4'-(1,2-ethenediyl)bis- |
CAS | 122-06-5 |
EINECS | 2045195 |
化学式 | C16H16N4 |
分子量 | 264.33 |
密度 | 1.1536 (rough estimate) |
沸点 | 397.56°C (rough estimate) |
溶解度 | DMSO |
折射率 | 1.6000 (estimate) |
存储条件 | -20℃ |
体外研究 | The high-affinity pentamidine transporter (HAPT1) is inhibited by Propamidine but displays only low affinity to Stilbamidine. adenosine-sensitive pentamidine transporter (ASPT1), in contrast, is strongly inhibited by Stilbamidine, and Propamidine. [ 3 H]pentamidine uptake is determined in the presence of various concentrations of adenosine (IC 50 =1.2 μM) or melarsen oxide (IC 50 =0.7 μM), as well as in the presence of 250 μM adenosine and increasing concentrations of hypoxanthine, Propamidine (IC 50 =6.1 μM) and Stilbamidine (IC 50 =110 μM). The two diamidine compounds, Stilbamidine and Pentamidine are used to treat in multiple myeloma, a disease in which increase of the globulin content of the serum is of frequent occurrence. |
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